澳门新莆京9288app官网(中国)有限公司

 

唐淳

教授,博士生导师

生物大分子动态学,生物物理化学,整合结构生物学

办公室:化学楼 B-205
电话:010-62758440
电子信箱:Tang_Chun@pku.edu.cn
课题组网站:http://www.tanglab.cn
http://tanglab.pku.edu.cn

本课题组每年招收1-2名博士后研究人员,欢迎联系

科研经历:

  • 2020 –,教授,博士生导师,北京大学澳门新莆京9288app官网
  • 2020 – ,研究员, 北大清华生命科学联合中心 / 北大定量生物学中心
  • 2010 – 2020, 研究员,中国科学院武汉物理与数学研究所,中国科学院生物磁共振分析重点实验室
  • 2008 – 2010,助理教授,美国密苏里大学,哥伦比亚分校
  • 2003 – 2008,博士后,美国国立健康研究院,合作导师 G. Marius Clore
  • 2003,理学博士,美国马里兰大学,巴尔的摩郡分校,导师 Michael F. Summers
  • 1998,理学学士,浙江大学生物系

 

奖项奖励:

  • “万人计划”科技创新领军人才(2019)
  • 科技部创新创业辅导师(2018)
  • 国务院政府特殊津贴 (2016)
  • “万人计划”青年拔尖人才(2014)
  • 国家杰出青年科学基金(2013)
  • 美国霍华德休斯国际青年科学家(2012)
  • 中国物理学会王天眷波谱学奖(2012)
  • 中国科学院“百人计划”(2011)

 

研究领域:

发展生物磁共振技术,发展顺磁核磁探针计算和相应算法,表征蛋白质、RNA等生物大分子的动态结构、动态相互作用,代表性论文有:
  1. Dong X, Qin LY, Gong Z, Qin Q, Zhou HX, Tang C (2022) Preferential interactions of a crowder protein with the specific binding site of a native protein complex” J Phys Chem. Lett,13:792–800
  2. Gong Z, Charles DS, Tang C (2018) Theory and practice of using solvent paramagnetic relaxation enhancement to characterize protein conformational dynamics. Methods, 148:48-56
  3. Gong Z, Gu XH, Guo DC, Wang J, Tang C. (2017). Protein structural ensembles visualized by solvent paramagnetic relaxation enhancement. Angew Chem Int Ed, 56:1002-1006
  4. Liu Z, Gong Z, Dong X, Tang C. (2016) Transient protein-protein interactions visualized by solution NMR. BBA Proteins Proteomics, 1864:115-122
  5. Xing Q, Huang P, Yang J, Sun JQ, Gong Z, Dong X, Guo DC, Chen SM, Yang YH, Wang Y, Yang MH, Yi M, Ding YM, Liu ML, Zhang WP, Tang C. (2014) Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling. Angew Chem Int Ed, 53:11501-11505

 

发展联合使用小角散射、单分子荧光、质谱交联等技术的整合生物物理化学方法,发展质谱交联数据的定量优化方法,表征非平衡态下的生物大分子的结构动态,代表性论文有:

  1. Ma Y, Li H, Gong Z, Yang S, Wang P, Tang C (2022) Nucleobase clustering contributes to the formation and hollowing of repeat-expansion RNA condensate J Am Chem Soc, 144:4716–4720
  2. Gong Z, Ye SX, Tang C. (2020) Tightening the crosslinking distance restraints for better resolution of protein structure and dynamics. Structure, 28:1160-1167
  3. Gong Z, Ye SX, Nie ZF, Tang C. (2020) The conformational preference of chemical crosslinkers determines the crosslinking probability of reactive protein residues. J Phy Chem B, 123:4446-4453
  4. Tang C, Gong Z. (2020) Integrating Non-NMR Distance restraints to augment NMR depiction of protein structure and dynamics. J Mol Biol, 432:2913-2929
  5. Ding YH, Gong Z, Dong X, Liu K, Liu Z, Liu C, He SM, Dong MQ, Tang C. (2017). Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem, 292:1187-1196

 

探究化学修饰、理化环境因素等对生物大分子结构动态的影响,重点关注泛素的磷酸化和 RNA的m6A甲基化对蛋白质、RNA构象的调控,代表性论文有:

  1. Tang C, Zhang WP. (2020) How phosphorylation by PINK1 remodels the ubiquitin system, a perspective from structure and dynamics. Biochemistry, 59:26-33
  2. You ZY, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Wang YS, Zhang HT, Peng C, Zhou TH, Tang C, Liu W. (2019) Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun, 10:5792
  3. Huang JB, Dong X, Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P, Tang C. (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10:272-284
  4. Dong X, Gong Z, Lu YB, Liu K, Qing LY, Ran ML, Zhang CL, Liu Z, Zhang WP, Tang C. (2017). Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci USA, 114:6770-6775
  5. Liu Z, Gong Z, Jiang WX, Yang J, Zhu WK, Guo DC, Zhang WP, Liu ML, Tang C. (2015) Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. eLife, 4:e05767
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