澳门新莆京9288app官网(中国)有限公司

 

吕华(Lu, Hua)

教授,博士生导师

研究方向:高分子化学

办公室:B105
办公室电话:010-62745285
电子信箱:Email@pku.edu.cn: chemhualu
课题组网站:www.chem.pku.edu.cn/luhua

研究兴趣:

高分子化学、可降解生物医用高分子材料、生物偶联、生物医药工程

教育经历:

  • 2006/08 – 2011/05 博士, 美国伊利诺伊大学香槟分校材料系
  • 2002/09 – 2006/07 学士,北京大学澳门新莆京9288app官网

工作经历

  • 2022/02 – 至 今 教授,北京大学澳门新莆京9288app官网
  • 2020/04 – 至 今 副主编,美国化学会期刊Biomacromolecules
  • 2020/02 – 2022/01 副教授(长聘),北京大学澳门新莆京9288app官网
  • 2014/02 – 2020/01 助理教授,北京大学澳门新莆京9288app官网
  • 2011/07 – 2014/05 博士后,Scripps研究所化学系

主要获奖及荣誉

  • 国家杰出青年科学基金(2021)
  • 北京大学青年教师基本大赛一等奖暨最受学生欢迎奖(2020)
  • 中国化学会高级会员(2020)
  • ACS PMSE Young Investigator(2020)
  • 日本高分子学会(SPSJ)International Leading Young Scientist(2020)
  • 中国化学会高分子青年学者奖(2019)
  • 中国化学会青年化学奖(2017)
  • 国家优秀青年科学基金(2017)
  • ACS-AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry(2013)
  • IUPAC Prize for Young Chemists, Honorable Mention(2012)
  • Damon Runyon癌症研究基金会博士后奖学金 (2011-2014)
  • 伊利诺伊大学材料系Racheff-Intel Award (Top Winner, 2011)
  • 第34届国际化学奥林匹克竞赛金牌(2002)

近五年代表论文

[1] Y. Hu, Z.-Y. Tian, W. Xiong, D. Wang, R. Zhao, Y.Xie, Y.-Q.Song, J. Zhu, and H. Lu*; “Water-Assisted and Protein-Initiated Fast and Controlled Ring-Opening Polymerization of Proline N-Carboxyanhydride”, Natl. Sci. Rev. 2022, DOI: 10.1093/nsr/nwac033.
[2] C. Dong; G. Wu; C. Chen; X. Li; R. Yuan; L. Xu; J. Zhang; H. Guo; J. Zhang; H. Lu*, and F. Wang*; “Site-specific Conjugation of a Selenopolypeptide to Alpha-1-antitrypsin Enhances Oxidation Resistance and Pharmacological Properties”, Angew. Chem. Int. Ed. 2022, 61, e2021152. (†equal contribution) (Hot Paper).
[3] Z.-Y. Tian; Z. Zhang; S. Wang; and H. Lu*, “A Moisture-Tolerant Route to Unprotected α/β-Amino Acid N-Carboxyanhydrides and Facile Synthesis of Hyperbranched Polypeptides”, Nat. Commun. 2021, 12, 5810.
[4] W. Xiong; W. Chang; D. Shi; L. Yang; Z.-Y. Tian; H. Wang; Z. Zhang; X. Zhou; E.-Q. Chen,* and H. Lu*, “Geminal Dimethyl Substitution Enables Controlled Polymerization of Penicillamine-Derived β-Thiolactones and Reversed Depolymerization”, Chem 2020, 6, 1831-1843. (Highlighted by Chem)
[5] J. Lu; H. Wang; Z.-Y. Tian; Y. Hou; and H. Lu*, “Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein-Polydisulfide Conjugates”, J. Am. Chem. Soc. 2020, 142, 1217-1221. (Selected as JACS Early Career Investigators Virtual Issue)
[6] J. Yuan; W. Xiong; X. Zhou; Y. Zhang; D. Shi; Z.-C. Li; and H. Lu*, “4-Hydroxyproline-Derived Sustainable Polythioesters: Controlled Ring-Opening Polymerization, Complete Recyclability, and Facile Functionalization”, J. Am. Chem. Soc. 2019, 141, 4928-4935 (ACS Editors’ Choice, Front Cover, also highlighted in Spotlights on Recent JACS Publications).
[7] Y. Hou; Y. Zhou; H. Wang; J. Sun; R. Wang; K. Sheng; J. Yuan; Y. Hu; Y. Chao; Z. Liu; and H. Lu*, “Therapeutic Protein PEPylation: The Helix of Nonfouling Synthetic Polypeptides Minimizes Antidrug Antibody Generation”, ACS Cent. Sci. 2019, 5, 229-236.
[8] Y. Hou and H. Lu*, “Protein PEPylation: A New Paradigm of Protein−Polymer Conjugation”, Bioconjugate Chem. 2019, 30, 1604-1616 (Invited Review).
[9] Y. Hou; Y. Zhou; H. Wang; R. Wang; J. Yuan; Y. Hu; K. Sheng; J. Feng; S. Yang; and H. Lu*, “Macrocyclization of Interferon-Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy”, J. Am. Chem. Soc. 2018, 140, 1170-1178. (highlighted by C&EN)
[10] Y. Hou; J. Yuan; Y. Zhou; J. Yu; and H. Lu*, “A Concise Approach to Site-Specific Topological Protein-Poly(amino acid) Conjugates Enabled by in Situ -Generated Functionalities”, J. Am. Chem. Soc. 2016, 138, 10995-11000.

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